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| 1833 |
| | | Under the leadership of William Lloyd Garrison a society is formed in the USA calling for the immediate abolition of slavery | |
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| 1836 |
| | | Sarah and Angelina Grimké join the abolitionist crusade, each publishing a powerful anti-slavery pamphlet in the same year | |
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| 1836 |
| | | The Portuguese ban the shipping of slaves from the coast of Angola | |
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| 1839 |
| | | Mutiny by slaves on a Spanish vessel leads two years later to a significant abolitionist victory in the Amistad case | |
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| c. 1841 |
| | | Britain sends four naval ships up the river Niger to make anti-slavery treaties with local kings | |
|  | Anti-slavery treaty with African chiefs
National Archives, Kew
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| 1845 |
| | | Escaped slave Frederick Douglass publishes the first of three volumes of autobiograrphy | |
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| 1848 |
| | | The Wilmot Proviso is defeated in the US Senate, heightening north-south tensions on the issue of slavery | |
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| c. 1850 |
| | | The Scottish missionary David Livingstone is profoundly shocked by what he sees of the slave trade at the heart of Africa | |
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| 1850 |
| | | The slave trade, but not slavery itself, is banned in Washington and the district of Columbia | |
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| 1850 |
| | | Brazil, historically the world's second largest importer of slaves from Africa, finally bans the slave trade | |
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